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Other than that, if you are allergic to black grapes or their extract, then it would be wise to avoid it. “However, if you plan to use black grape extract directly onto your skin, begin with a patch test. You can do the patch test on inconspicuous areas of your skin, like your wrist or ankle. Wait for 24 hours to ensure that your skin has no adverse reaction to the extract and can handle it,” advised Pandharipande, highlighting that if you are allergic to the extract, you might develop blisters on your skin, including more serious side effects like difficulty in breathing, rashes, itching, swelling on lips, tongu,e and throat. In such a scenario, it is advisable to contact your physician immediately.